Glucosamine + Chondroitin

What is glucosamine + chondroitin?

Glucosamine + chondroitin combination (brand names: Cosequin®, Dasuquin®, Dasuquin Advanced®, Glycoflex®, NutriVet®, Next Level®, AniFlex®, Phycox®, Restor-A-Flex®, OsteO-3®, Arthri-Nu®, ProMotion®, Seraquin®, Oste-OGuard®, Caniflex®, and Equi-Phar Flex®) is a nutritional supplement used to treat osteoarthritis in dogs, cats, miniature pigs, and other animals, as well as feline lower urinary tract disease (FLUTD) in cats.

Glucosamine acts as a mild anti-inflammatory and is used by the joints to make cartilage components and by the urinary tract for protection. Chondroitin inhibits destruction and promotes production of cartilage components. Sometimes glucosamine and chondroitin are used in combination with other joint supplement nutrients.

The U.S. Food and Drug Administration (FDA) does not review non-drug health products (e.g., herbals, nutraceuticals, shampoos, and other supplements) for safety or effectiveness before they are sold to the public. Manufacturers of non-drug health products must ensure their products are safe and labeled accurately. 

The FDA requires that these non-pharmaceuticals contain a disclaimer that says, “This product is not intended to diagnose, treat, cure or prevent any disease.” Health Canada licenses “veterinary health products” after reviewing safety, efficacy, and manufacturing information provided by the manufacturer. These products are not tested by Health Canada.

Your veterinarian is the best source of information about the safety of non-drug health products in pets. Just because a product is natural does not mean it is safe. All medicines and medicinal plants are potentially toxic if used inappropriately or given at high doses. 

Supplements can also have side effects, like pharmaceuticals. Few supplements and herbs have been subjected to rigorous scientific trials to determine their efficacy.

Although the information in this handout may be helpful, it also may be incomplete and may not represent the full range of effects the supplement could have on your pet.

How is glucosamine + chondroitin given?

• Glucosamine + chondroitin comes in liquid, powder, capsule, and tablet forms.
• All forms are given orally (by mouth).
• Oral forms may be given with or without food.
• Measure liquid doses carefully.
• Use caution when switching brands, as active ingredients may not be the same between brands.
• Follow your veterinarian’s instructions on administering this medication carefully and give for the entire time prescribed by your veterinarian, even if your pet is feeling better.

This medication may take several weeks before full effects are seen, although outward improvements may be noticeable after a few days.

What if I miss giving my pet the supplement?

If you miss a dose, give it as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and resume the regular dosing schedule. Do not give the pet two doses at once.

Are there any potential side effects?

Glucosamine + chondroitin may cause the following side effects:

• Mild gastrointestinal upset (gas, soft stools)

Serious adverse reactions may occur. If any of the following signs develop, stop giving glucosamine + chondroitin and contact your veterinarian immediately:

• An allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses, but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This short-acting medication should stop working within 24 hours, although effects may last longer in pets with liver and/or kidney disease.

Are there any risk factors for this supplement?

DO NOT USE glucosamine + chondroitin in:

• Pets that are allergic to any component of the medication

USE WITH CAUTION in:

• Pets with asthma or illnesses that cause bronchoconstriction
• Pets that require a low potassium diet
• Pets that are pregnant or lactating

Are there any drug interactions I should be aware of?

The following medications should be used WITH CAUTION when given with glucosamine + chondroitin:

• Certain NSAIDs (e.g. firocoxib, diclofenac, carprofen)
• Doxorubicin
• Heparin
• Insulin and other antidiabetic agents
• Sertraline
• Warfarin

Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this supplement?

• Follow your veterinarian’s directions for follow-up visits and diagnostics.
• At home, monitor for any abnormal changes. If these occur, discontinue the medication and contact your veterinarian.

How do I store glucosamine + chondroitin?

• Store the medication according to the manufacturer’s directions.
• Protect from light.
• Keep medication out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet’s weight and symptoms.